PUBLICATIONS
& PRESENTATIONS
From Collaborating Labs
Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression.
Al-Dabet, M. M.; Shahzad, K.; Elwakiel, A.; Sulaj, A.; Kopf, S.; Bock, F.; Gadi, I.; Zimmermann, S.; Rana, R.; Krishnan, S.; Gupta, D.; Nazir, S.; Geffers, R.; Mertens, P.; Nawroth, P. P.; Griffin, J.; Dockendorff, C.; Kohli, S.*; Isermann, B.*
Nature Communications 2022, 13, 5062.
A Thrombin-PAR1/2 Feedback Loop Amplifies Thrombo-Inflammatory Endothelial Responses To The Viral RNA Analogue Poly(I:C).
Subramaniam, S.; Ogoti, Y.; Hernandez, I.; Zogg, M.; Botros, F.; Burns, R. T.; DeRousse, J. T.; Dockendorff, C.; Mackman, N.; Antoniak, S.; Fletcher, C.; Weiler, H.
Blood Advances 2021, 5, 2760–2774.
The parmodulin NRD-21 is a biased allosteric inhibitor of PAR1 Gq signaling with improved anti-inflammatory activity and stability.
Gandhi, D. M.; Rosas, Jr., R.; Greve, E.; Kentala, K.; Diby, N. D.-R.; Snyder, V. A.; Stephans, A.; Yeung, T. H. W.; Subramaniam, S.; DiMilo, E.; Kurtenbach, K. E.; Arnold, L. A.; Weiler, H.; Dockendorff, C.*
Bioorg. Med. Chem. 2019, 27, 3788–3796.
Characterization of Protease-Activated Receptor (PAR) ligands: Parmodulins are reversible allosteric inhibitors of PAR1-driven calcium mobilization in endothelial cells.
Gandhi, D. M.; Majewski, M. W.; Rosas, Jr., R.; Kentala, K.; Foster, T. J.; Greve, E.; Dockendorff, C.*
Bioorg. Med. Chem. 2018, 26, 2514–2529.
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury.
De Ceunynck, K.; Peters, C. G.; Jain, A.; Higgins, S. J.; Aisiku, O.; Fitch-Tewfik, J. L.; Chaudhry, S. A.; Dockendorff, C.; Parikh, S. M.; Ingber, D. E.; Flaumenhaft, R.*
Proc. Nat. Acad. Sci. USA 2018, 115, E982–E991.
Cytoprotective activated protein C ameliorates Nlrp3 inflammasome induced ischemia reperfusion 1 injury via mTORC1 inhibition.
Nazir, S.; Gadi, I.; Al-Dabet, M. M.; Elwakiel, A.; Kohli, S.; Ghosh, S.; Manoharan, J.; Ranjan, S.; Bock, F.; Braun-Dullaeus, R. C.; Esmon, C. T.; Huber, T. B.; Camerer, E.; Dockendorff, C.; Griffin, J. H.; Isermann, B.*; Shahzad, K.*
Blood 2017, 130, 2664–2677.
Discovery of 1,3-Diaminobenzenes as Selective Inhibitors of Platelet Activation at the PAR1 Receptor.
Dockendorff, C.*; Aisiku, O.; VerPlank, L.; Dilks, J. R.; Smith, D. A.; Gunnink, S. F.; Dowal, L.; Negri, J.; Palmer, M.; MacPherson, L.; Schreiber, S. L.; Flaumenhaft, R.*
ACS Med. Chem. Lett. 2012, 3, 232–237.